The items identified in this supplement are a subset of items that are otherwise designated as EAR99 under the Commerce Control List (CCL) in supplement no. 1 to part 774. These items may be useful for Russia's chemical and biological weapons production capabilities or may be diverted from Belarus to Russia for these or other activities of concern. These items consist of discrete chemicals, biologics, fentanyl and its precursors, and related equipment. BIS has specified Chemical Abstract Numbers (CAS) where applicable in this supplement to assist exporters, reexporters, and transferors in classifying these items. In addition, paragraph (g) of supplement no. 6 to part 746 identifies equipment and other items that BIS has determined are not manufactured in Russia or are otherwise important to Russia in developing advanced production and development capabilities to enable advanced manufacturing across a number of industries or may be diverted from Belarus to Russia for these or other activities of concern. This supplement does not include any item that meets the definition of “medicine” in § 772.1 of the EAR.

(a) Chemicals in concentrations of 95% weight or greater, as follows:

(1) Ethylene dichloride (CAS 107-06-2); (2) Nitromethane (CAS 75-52-5); (3) Picric acid (CAS 88-89-1); (4) Aluminum chloride (CAS 7446-70-0); (5) Arsenic (CAS 7440-38-2); (6) Arsenic trioxide (CAS 1327-53-3); (7) Bis(2-chloroethyl)ethylamine hydrochloride (CAS 3590-07-6); (8) Bis(2-chloroethyl)methylamine hydrochloride (CAS 55-86-7); (9) Tris(2-chloroethyl)amine hydrochloride (CAS 817-09-4); (10) Tributylphosphite (CAS 102-85-2); (11) Isocyanatomethane (CAS 624-83-9); (12) Quinaldine (CAS 91-63-4); (13) 2-bromochloroethane (CAS 107-04-0); (14) Benzil (CAS 134-81-6); (15) Diethyl ether (CAS 60-29-7); (16) Dimethyl ether (CAS 115-10-6); (17) Dimethylaminoethanol (CAS 108-01-0); (18) 2-methoxyethanol (CAS 109-86-4); (19) Butyrylcholinesterase (BCHE); (20) Diethylenetriamine (CAS 111-40-0); (21) Dichloromethane (CAS 75-09-2); (22) Dimethylaniline (CAS 121-69-7); (23) Ethyl bromide (CAS 74-96-4); (24) Ethyl chloride (CAS 75-00-3); (25) Ethylamine (CAS 75-04-7); (26) Hexamine (CAS 100-97-0); (27) Isopropanol (CAS 67- 63-0); (28) Isopropyl bromide (CAS 75-26-3); (29) Isopropyl ether (CAS 108-20-3); (30) Methylamine (CAS 74-89-5); (31) Methyl bromide (CAS 74-83-9); (32) Monoisopropylamine (CAS 75-31-0); (33) Obidoxime chloride (CAS 114-90-9); (34) Potassium bromide (CAS 7758-02-3); (35) Pyridine (CAS 110-86-1); (36) Pyridostigmine bromide (CAS 101-26-8); (37) Sodium bromide (CAS 7647-15-6); (38) Sodium metal (CAS 7440-23-5); (39) Tributylamine (CAS 102-82-9); (40) Triethylamine (CAS 121-44-8); (41) Trimethylamine (CAS 75-50-3); (42) Lithium chloride (CAS 7447-41-8); (43) Lithium chloride hydrate (CAS 85144-11-2); (44) Lithium chloride monohydrate (CAS 16712-20-2); or (45) Lithium carbonate (CAS 554-13-2).

(b) Chemicals in concentrations of 90% weight or greater, as follows:

(1) Acetone (CAS 67-64-1); (2) Acetylene (CAS 74-86-2); (3) Ammonia (CAS 7664-41-7); (4) Antimony (CAS 7440-36-0); (5) Benzaldehyde (CAS 100-52-7); (6) Benzoin (CAS 119-53-9); (7) 1-Butanol (CAS 71-36-3); (8) 2-Butanol (CAS 78-92-2); (9) Iso-Butanol (CAS 78-83-1); (10) Tert-Butanol (CAS 75-65-0); (11) Calcium carbide (CAS 75-20-7); (12) Carbon monoxide (CAS 630-08-0); (13) Chlorine (CAS 7782-50-5); (14) Cyclohexanol (CAS 108-93-0); (15) Dicyclohexylamine (CAS 101-83-7); (16) Ethanol (CAS 64-17-5); (17) Ethylene (CAS 74-85-1); (18) Ethylene oxide (CAS 75-21-8); (19) Fluoroapatite (CAS 1306-05-4); (20) Hydrogen chloride (CAS 7647-01-0); (21) Hydrogen sulfide (CAS 7783-06-4); (22) Mandelic acid (CAS 90-64-2); (23) Methanol (CAS 67-56-1); (24) Methyl chloride (CAS 74-87-3); (25) Methyl iodide (CAS 74-88-4); (26) Methyl mercaptan (CAS 74-93-1); (27) Monoethyleneglycol (CAS 107-21-1); (28) Oxalyl chloride (CAS 79-37-8); (29) Potassium sulfide (CAS 1312-73-8); (30) Potassium thiocyanate (CAS 333-20-0); (31) Sodium hypochlorite (CAS 7681-52-9); (32) Sulphur (CAS 7704-34-9); (33) Sulphur dioxide (CAS 7446-09-5); (34) Sulphur trioxide (CAS 7446-11-9); (35) Thiophosphoryl chloride (CAS 3982-91-0); (36) Tri-isobutyl phosphite (CAS 1606-96-8); (37) White phosphorus (CAS 12185-10-3); or (38) Yellow phosphorus (CAS 7723-14-0).

(c) Fentanyl and its derivatives Alfentanil, Sufentanil, Remifentanil, Carfentanil, thiafentanil and salts thereof.

Note 1 to paragraph (c):

The items in paragraph (c) are from the EU list, as X.C.IX.002.

Note 2 to paragraph (c):

Consistent with EU List X.C.IX.002, paragraph (c) does not control products identified as consumer goods packaged for retail sale for personal use or packaged for individual use.

(d) Chemical precursors to Central Nervous System Acting Chemicals, as follows:

(1) 4-anilino-N-phenethylpiperidine (CAS 21409-26-7);

(2) N-phenethyl-4-piperidone (CAS 39742-60-4);

(3) Tert-butyl 4-(phenylamino) piperidine-1-carboxylate (CAS 125541-22-2);

(4) N-phenyl-N-(piperidin-4-yl)propionamide (Norfentanyl) (CAS 1609-66-1); or

(5) N-phenyl-4-piperidinamine (CAS 504-24-5).

Note 3 to paragraph (d):

The items in paragraph (d) are from the EU list, as X.C.IX.003.

Note 4 to paragraph (d):

Consistent with EU List X.C.IX.003, paragraph (d) does not control “chemical mixtures” containing one or more of the chemicals specified in paragraph (d) (and consistent with EU List entry X.C.IX.003) in which no individually specified chemical constitutes more than 1% by the weight of the mixture.

Note 5 to paragraph (d):

Consistent with EU List X.C.IX.003, paragraph (d) does not control products identified as consumer goods packaged for retail sale for personal use or packaged for individual use.

(e) Biologics: This paragraph (e) identifies certain biologics and biological equipment. The control on these items is intended to hinder Russia bioweapons production capabilities.

(1) Butyrylcholinesterase (BCHE);

(2) Cell culture materials, including cell lines, vectors, plasmids, and cell culture media, n.e.s.;

(3) Assay kits and reagents for nucleotide or peptide isolation, extraction, or purification, n.e.s.;

(4) Isolated or purified nucleotides and oligonucleotides, n.e.s.;

(5) Isolated or purified amino acids, peptides and proteins, n.e.s.;

(6) Reagents and materials for oligonucleotide synthesis, n.e.s.; or

(7) Resins, reagents, and materials for peptide synthesis, n.e.s.

(f) Equipment and consumable “materials. This paragraph (f) identifies additional equipment and consumable “materials” that BIS has determined are not manufactured in Russia. Therefore, the implementation of restrictive export controls on these items by the United States and our allies will economically impact Russia and significantly hinder Russia's CBW production capabilities.

(1) Reaction vessels, agitators, heat exchangers, condensers, pumps (including single seal pumps), valves, storage tanks, containers, receivers, and distillation or absorption columns, n.e.s.;

(2) Vacuum pumps with a manufacturer's specified maximum flow-rate greater than 1 m 3/h (under standard temperature and pressure conditions), casings (pump bodies), preformed casing-liners, impellers, rotors, and jet pump nozzles designed for such pumps; n.e.s.;

(3) Laboratory equipment, including “components,” “parts,” “accessories,” and consumable “materials” for such equipment, for the analysis or detection, destructive or non-destructive, of chemical substances, n.e.s.;

(4) Whole chlor-alkali electrolysis cells (mercury, diaphragm, and membrane) and “components” “specially designed” therefor as follows:

(i) Electrodes;

(ii) Diaphragms; and

(iii) Ion exchange membranes;

(5) Compressors “specially designed” to compress wet or dry chlorine, regardless of material of construction;

(6) Class II biosafety cabinets and glove boxes, n.e.s.;

(7) Floor-mounted fume hoods (walk-in style) with a minimum nominal width of 2.5 meters, n.e.s.;

(8) Full face-mask air-purifying and air-supplying respirators n.e.s.;

(9) Conventional or turbulent air-flow clean-air rooms and self-contained fan-HEPA filter units that may be used for P3 or P4 (BSL 3, BSL 4, L3, L4) containment facilities;

(10) Microwave reactors;

(11) Well plates and microarrays;

(12) Fermenters and components therefor, n.e.s.;

(13) Centrifuges and ultracentrifuges capable of separating biological samples, with a maximum capacity of 5L, “components” and “accessories” therefor, n.e.s., including centrifuge tubes and concentrators;

(14) Filtration equipment, “components,” “parts,” and “accessories,” capable of use in handling biological materials, n.e.s.;

(15) Nucleic acid synthesizers and assemblers, “components,” “parts,” and “accessories,” n.e.s.;

(16) Polymerase chain reaction (PCR) and quantitative PCR (qPCR) instruments “components,” “parts,” and “accessories;”

(17) Robotic liquid handling instruments, “components,” “parts,” and “accessories,” n.e.s.;

(18) Chromatography and spectrometry “components,” “parts,” and “accessories,” n.e.s.;

(19) Nucleic acid sequencers, “components,” “parts,” and “accessories;”

(20) Aerosol inhalation testing equipment, components, parts and accessories, n.e.s.;

(21) Flow cytometry equipment, components, parts and accessories, n.e.s.;

(22) Probe sonicators, cell disruptors and tissue homogenizers;

(23) 'Continuous flow reactors' and their 'modular components,' “parts,” and “accessories,” n.e.s;

Technical Notes for paragraph (f)(23):

1. Consistent with EU List X.B.X.001, for purposes of paragraph (f)(23) 'continuous flow reactors' consist of plug and play systems where reactants are continuously fed into the reactor and the resultant product is collected at the outlet.

2. Consistent with EU List X.B.X.001, for purposes of paragraph (f)(23) 'modular components' are fluidic modules, liquid pumps, valves, packed-bed modules, mixer modules, pressure gauges, liquid-liquid separators, etc.

(24)—(26) [Reserved]

(27) Peptide synthesizers, “components,” “parts,” and “accessories.”

Note 6 to paragraph (f):

Consistent with the definitions in part 772 of the EAR, “components,” “parts,” “accessories,” and “materials” include consumables.

(g) Quantum computing and advanced manufacturing: This paragraph (g) identifies additional equipment and other items that are believed to not be manufactured in Russia or are otherwise important to Russia in developing advanced production and development capabilities.

(1) 'Quantum Computers', and “specially designed” “electronic assemblies” and “components” therefor, as follows:

(i) Quantum processing units, qubit circuits, and qubit devices;

(ii) Quantum control “components” and quantum measurement devices.

Note 7 to paragraph (g)(1):

Quantum processing units, qubit circuits and qubit devices include but are not limited to semiconductor, superconducting, Ion Trap, photonic interaction, silicon/spin, cold atoms.

Note 8 to paragraph (g)(1):

Quantum control “components” and quantum measurement devices applies to items designed for calibrating, initializing, manipulating or measuring the resident qubits of a quantum computer.

(2) 'Cryogenic refrigeration systems' designed to maintain temperatures below 1.1k for 48hrs or more and “specially designed” cryogenic refrigeration equipment and “components” as follows:

(i) Pulse Tubes;

(ii) Cryostats;

(iii) Dewars;

(iv) Gas Handling System (GHS);

(v) Compressors;

(vi) Control Units;

Note 9 to paragraph (g)(2): 'Cryogenic refrigeration systems' include but are not limited to Dilution Refrigeration, Adiabatic Demagnisation Refrigerators and Laser Cooling Systems.

(3) Ultra-High Vacuum (UHV) equipment as follows:

(i) UHV pumps (sublimation, turbomolecular, diffusion, cryogenic, ion-getter);

(ii) UHV pressure gauges.

Note 10 to paragraph (g)(3):

UHV means 100 nanoPascals (nPa) or lower.

(4) High Quantum Efficiency (QE) photodetectors and sources with a QE greater than 80% in the wavelength range exceeding 300nm but not exceeding 1700nm;

(5) Manufacturing equipment as follows:

(i) Additive manufacturing equipment for the production of metal parts;

Note 11 to paragraph (g)(5)(i):

This entry identified under paragraph (5)(i) only applies to the following systems:

1. Powder-bed systems using Selective Laser Melting (SLM), laser cusing; Direct Metal Laser Sintering (DMLS) or Electron Beam Melting (ELB), or

2. Powder-fed systems using laser cladding, direct energy deposition or laser metal deposition.

(ii) Additive manufacturing equipment for “energetic materials”, including equipment using ultrasonic extrusion;

(iii) Vat photopolymerisation additive manufacturing equipment using Stereo Lithography (SLA) or Direct Light Processing (DLP)

(6) Metal powders and metal alloy powders “specially designed” for the additive manufacturing equipment specified in 3a.

(7) Microscopes, related equipment and detectors, as follows:

(i) Scanning Electron Microscopes (SEM);

(ii) Scanning Auger Microscopes;

(iii) Transmission Electron Microscopes (TEM);

(iv) Atomic Force Microscopes (AFM);

(v) Scanning Force Microscopes (SFM);

(vi) Equipment and detectors “specially designed” for use with the microscopes specified in a. to e., employing any of the following:

(A) X-ray Photo Spectroscopy (XPS):

(B) Energy-Dispersive X-ray Spectroscopy (EDX, EDS);

(C) Electron Back Scatter Detector (EBSD) systems;

(D) Electron Spectroscopy for Chemical Analysis (ESCA).

(8) 'Decapsulation' equipment for semiconductor devices.

Note 12 to paragraph (g)(8):

'Decapsulation' is the removal of a cap, lid, or encapsulating material from a packaged integrated circuit by mechanical, thermal, or chemical methods.

(9) “Software” “specially designed” or modified for the “development”, “production” or “use” of the items specified in paragraphs (g)(1) through (8) of this supplement.

(10) “Software” for Digital Twins (DT) of additive manufacture products or for the determination of the reliability of additive manufacture products.

(11) “Technology” for the “development”, “production” or “use” of the items specified in paragraphs (g)(1) through (10) of this supplement.

(h) Riot Control Agents which are isomers of CS (o-Chlorobenzylidenemalononitrile or o-Chlorobenzalmalononitrile) (CAS 2698-41-1); CN (Phenylacyl chloride or w-Chloroacetophenone) (CAS 532-27-4); or Oleoresin Capsicum (CAS 8023-77-6) as follows:

(1) 8-Methyl-N-vanillyl-trans-6-nonenamide (Capsaicin) (CAS 404-86-4);

(2) 8-Methyl-N-vanillylnonamide (Dihydrocapsaicin) (CAS 19408-84-5);

(3) N-Vanillylnonamide (Pseudocapsaicin, PAVA) (CAS 2444-46-4);

(4) N-Vanillyl-9-methyldec-7-(E)-enamide (Homocapsaicin) (CAS 58493-48-4);

(5) N-Vanillyl-9-methyldecanamide (Homodihydrocapsaicin) (CAS 20279-06-5);

(6) N-Vanillyl-7-methyloctanamide (Nordihydrocapsaicin) (CAS 28789-35-7);

(7) 2′-chloroacetophenone (CAS 2142-68-9);

(8) 3′-chloroacetophenone (CAS 99-02-5);

(9) α-chlorobenzylidenemalononitrile (CAS 18270-61-6); and

(10) Cis-4-acetylaminodicyclohexylmethane (CAS 37794-87-9).

(i) Pre-cursors for riot control agents and chloropicrin as follows:

(1) Malononitrile (CAS 109-77-3);

(2) 2-Chlorobenzaldehyde (CAS 89-98-5);

(3) 2-Chlorobenzyl Alcohol (CAS 17849-38-6);

(4) 2-Chlorobenzylamine (CAS 89-97-4);

(5) Benzene, 1-chloro-2-(dimethoxymethyl) (CAS 70380-66-4);

(6) Acetophenone (CAS 98-86-2);

(7) Chloroacetyl Chloride (CAS 79-04-9);

(8) Chloroform (CAS 67-66-3); and

(9) o-Aminophenol (CAS 95-55-6).

[87 FR 57104, Sept. 16, 2022, as amended at 88 FR 12204, Feb. 27, 2023; 88 FR 33469, May 23, 2023; 89 FR 4815, Jan 25, 2024; 89 FR 51678, June 18, 2024; 89 FR 87282, Nov. 1, 2024]